Rabbit anti-Human CD69  Monoclonal Antibody | anti-CD69  antibody

Rabbit anti Human CD69  Monoclonal Antibody

Cat. Num. AAA2544186

• Gene Names: CD69; AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26
• Reactivity: Human
• Applications: Western Blot, ELISA, Immunoprecipitation
• Synonyms: CD69 ; Monoclonal Antibody; Rabbit anti Human CD69 Monoclonal Antibody; anti-CD69 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 21

• Applicable Applications for anti-CD69 antibody: Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Application Notes: WB: 10-20 mug/mL; ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CD69. The detection limit for Human CD69 is approximately 0.0049 ng/well.; IP: 4-6 mug/mg of lysate
• Immunogen: Recombinant Human CD69 Protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CD69  antibody

Early activation antigen CD69, also known as activation inducer molecule (AIM), is a single-pass type II membrane protein. Recently, cDNA clones encoding human and mouse CD69 were isolated and showed CD69 to be a member of the C-type lectin superfamily. It is one of the earliest cell surface antigens expressed by T cells following activation. Once expressed, CD69 acts as a costimulatory molecule for T cell activation and proliferation. In addition to mature T cells, CD69 is inducibly expressed by immature thymocytes, B cells, natural killer (NK) cells, monocytes, neutrophils and eosinophils, and is constitutively expressed by mature thymocytes and platelets. CD69 is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. The structure, chromosomal localization, expression and function of CD69 suggest that it is likely a pleiotropic immune regulator, potentially important in the activation and differentiation of a wide variety of hematopoietic cells. This membrane molecule transiently expresses on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. CD69 plays a crucial role in the pathogenesis of allergen-induced eosinophilic airway inflammation and hyperresponsiveness and that CD69 could be a possible therapeutic target for asthmatic patients.

NCBI and Uniprot Product Information

• NCBI GI #: 793838
• NCBI GeneID: 969
• UniProt Accession #: Q6LAB3; Q07108
• Molecular Weight: 2,282 Da
• NCBI Official Full Name: CD69, partial
• NCBI Official Synonym Full Names: CD69 molecule
• NCBI Official Symbol: CD69
• NCBI Official Synonym Symbols: AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26
• NCBI Protein Information: early activation antigen CD69
• UniProt Protein Name: CD69 protein
• UniProt Gene Name: CD69
• UniProt Entry Name: Q6LAB3_HUMAN

NCBI Description

This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]