Testing Data
(Figure A. FITC conjugated Rat anti Human CD8 and purified Mouse IgG1 isotype control detected with RPE conjugated Goat anti Mouse IgG1 . Figure B. FITC conjugated Rat anti Human CD8 and purified Mouse anti Human CD352 detected with RPE conjugated Goat anti Mouse IgG1 . All experiments performed on human blood gated on live single cell lymphocytes in the presence of human serum. Data acquired on the ZE5 Cell Analyzer)
Mouse anti-Human CD352 Monoclonal Antibody | anti-CD352 antibody
Mouse Anti Human CD352: FITC
Use 10ul of the suggested working dilution to label 106 cells in 100ul
This product should be stored undiluted.
Storage in frost free freezers is not recommended.
Avoid repeated freezing and thawing as this may denature the antibodyd.
This product contains a precipitate we recommend microcentrifugation before use.
Testing Data
(Figure A. FITC conjugated Rat anti Human CD8 and purified Mouse IgG1 isotype control detected with RPE conjugated Goat anti Mouse IgG1 . Figure B. FITC conjugated Rat anti Human CD8 and purified Mouse anti Human CD352 detected with RPE conjugated Goat anti Mouse IgG1 . All experiments performed on human blood gated on live single cell lymphocytes in the presence of human serum. Data acquired on the ZE5 Cell Analyzer)
Testing Data
(Figure A. FITC conjugated Rat anti Human CD8 and purified Mouse IgG1 isotype control detected with RPE conjugated Goat anti Mouse IgG1 . Figure B. FITC conjugated Rat anti Human CD8 and purified Mouse anti Human CD352 detected with RPE conjugated Goat anti Mouse IgG1 . All experiments performed on human blood gated on live single cell lymphocytes in the presence of human serum. Data acquired on the ZE5 Cell Analyzer)
CD352 is a 60 kDa, transmembrane glycoprotein member of the signaling lymphocyte activating molecule (SLAM) family of receptors. Expressed by natural killer (NK) cells, B cells and T cells, CD352 is an immunoregulatory receptor with a roles in both innate and adaptive immune responses. The SLAM receptors control NK cell activation. Activation and phosphorylation of CD352 on the surface of NK cells induces cytotoxicity and cytokine production.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Uniprot Description
SLAMF6: Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component: integral to membrane; plasma membrane
Molecular Function: receptor activity
Research Articles on CD352
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Product Notes
The CD352 slamf6 (Catalog #AAA225803) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti Human CD352: FITC reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD352 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). FC/FACS: Min. Dilution: Neat Use 10ul of the suggested working dilution to label 106 cells in 100ul. Researchers should empirically determine the suitability of the CD352 slamf6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD352, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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