Rabbit anti-Human CD200  Monoclonal Antibody | anti-CD200  antibody

Rabbit anti Human CD200  Monoclonal Antibody

Cat. Num. AAA2544105

• Gene Names: CD200; MRC; MOX1; MOX2; OX-2
• Reactivity: Human
• Applications: ELISA
• Synonyms: CD200 ; Monoclonal Antibody; Rabbit anti Human CD200 Monoclonal Antibody; anti-CD200 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 269

• Applicable Applications for anti-CD200 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human CD200. The detection limit for Human CD200 is 0.00975 ng/well.
• Immunogen: Recombinant Human CD200 protein
• Buffer: This antibody was obtained from a rabbit immunized with purified, recombinant Human CD200 (rh CD200; NP_005935.4; Met 1-Gly 232).
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-CD200  antibody

CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in a number of human malignancies. In addition, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.

NCBI and Uniprot Product Information

• NCBI GI #: 119600082
• NCBI GeneID: 4345
• Molecular Weight: 32,975 Da
• NCBI Official Full Name: CD200 antigen, isoform CRA_a
• NCBI Official Synonym Full Names: CD200 molecule
• NCBI Official Symbol: CD200
• NCBI Official Synonym Symbols: MRC; MOX1; MOX2; OX-2
• NCBI Protein Information: OX-2 membrane glycoprotein
• UniProt Protein Name: OX-2 membrane glycoprotein
• UniProt Gene Name: CD200
• UniProt Synonym Gene Names: MOX1; MOX2
• UniProt Entry Name: OX2G_HUMAN

NCBI Description

This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Uniprot Description

CD200: Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q13.2

Cellular Component: cell-cell adherens junction; integral to plasma membrane; plasma membrane

Molecular Function: cell adhesion molecule binding; protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion; regulation of immune response