Mouse anti-Human CD11/CD18 Monoclonal Antibody | anti-CD11/CD18 antibody
Mouse anti CD11/CD18 [24]: Fluorescein
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunofluorescence
Purity
Purified on protein A from tissue culture supernatant.
Synonyms
CD11/CD18; Monoclonal Antibody; Mouse anti CD11/CD18 [24]: Fluorescein; Integrin alpha (L; M; X)/beta 2; anti-CD11/CD18 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
24
Specificity
This antibody recognises integrin alpha L,M,X/Beta 2 (CD11/CD18). Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits which mediate cell-cell and cell-extracellular matrix attachments. Integrin beta2 (CD18) associates with integrin alpha L (CD11a) to form the leukocyte function-associated antigen-1 (LFA-1) with integrin alpha M (CD11b) to form Complement Receptor 3 (CR3) and with integrin alpha X (CD11c) to form Complement Receptor 4 (CR4). Each integrin receptor can bind various Intercellular adhesion molecules (ICAMs). Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.
Purity/Purification
Purified on protein A from tissue culture supernatant.
Form/Format
Purified IgG conjugated to Fluorescein, supplied in Phosphate buffered saline (PBS) containing 0.09% Sodium azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CD11/CD18 antibody
Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes
Optimal antibody dilution should be determined by titration
Target Antigen
CD11/CD18
Immunogen
Fibronectin-purified human monocytes
Myeloma/fusion Partners
Cells from immunized Balb/c mice were fused with the Sp2/0-Ag.14 myeloma cell line
Research Areas
Cell adhesion; Immune response
References
Hogg N, et al. An anti-human monocyte/macrophage monoclonal antibody, reacting most strongly with macrophages in lymphoid tissue. Cell Immunol. 1985. 92(2):247-53. PMID:2581704 http://www.ncbi.nlm.nih.gov/pubmed/2581704
Similar Products
Product Notes
The CD11/CD18 (Catalog #AAA375382) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti CD11/CD18 [24]: Fluorescein reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD11/CD18 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF). Optimal antibody dilution should be determined by titration. Researchers should empirically determine the suitability of the CD11/CD18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD11/CD18, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
