Testing Data
(Intracellular staining of MCF-7 cells with MBS608033 (filled histogram) or PE-conjugated isotype control (open histogram).)
Mouse anti-Human ADAM15 Monoclonal Antibody | anti-ADAM15 antibody
ADAM15 (a Disintegrin and Metalloprotease 15, Metargidin, MDC15) (PE)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Testing Data
(Intracellular staining of MCF-7 cells with MBS608033 (filled histogram) or PE-conjugated isotype control (open histogram).)
Testing Data
(Intracellular staining of MCF-7 cells with MBS608033 (filled histogram) or PE-conjugated isotype control (open histogram).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
Uniprot Description
ADAM15: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. 11 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; EC 3.4.24.-; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: cell projection; cell surface; adherens junction; acrosome; integral to membrane; plasma membrane
Molecular Function: integrin binding; protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; SH3 domain binding
Biological Process: integrin-mediated signaling pathway; extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; apoptosis; tissue regeneration; cell-matrix adhesion; innate immune response; negative regulation of cell growth; angiogenesis; proteolysis; negative regulation of cell-matrix adhesion; negative regulation of cell migration
Research Articles on ADAM15
2. Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins SNX33 and nephrocystin
3. analysis of the ADAM15 disintegrin domain and its binding properties
4. Insights into the mechanism of how a splice variant linked to clinical agressiveness in breast cancer causes increased activity of ADAM15B.
5. involved in advanced atherosclerosis, in catalytically active form, most notably associated with cells of monocytic origin
6. results define key catalytic properties of ADAM15 in cells and its response to stimulators and inhibitors of ectodomain shedding.
7. Observational study of gene-disease association. (HuGE Navigator)
8. Recombinant ADAM15 disintegrin domain inhibits melanoma cell proliferation partly through p38 kinase activation.
9. This presents a novel mechanism by which ADAM15 regulates cell-matrix adhesion and migration.
10. ADAM15 catalyzes the cleavage of E-cadherin to generate a soluble fragment that in turn binds to and stimulates ErbB receptor signaling
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Product Notes
The ADAM15 adam15 (Catalog #AAA608033) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ADAM15 (a Disintegrin and Metalloprotease 15, Metargidin, MDC15) (PE) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ADAM15 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Dilution: Flow Cytometry: 10ul labels up to 1x10e6 cells. Researchers should empirically determine the suitability of the ADAM15 adam15 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADAM15, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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