SDS-Page
MARCO recombinant protein
MARCO Protein, Mouse, Recombinant (His Tag)
Gene Names
Marco; Ly112; Scara2; AI323439
Purity
>92% as determined by SDS-PAGE
Synonyms
MARCO; MARCO Protein; Mouse; Recombinant (His Tag); Mouse MARCO Protein (His Tag); AI323439 Protein; Ly112 Protein; Scara2 Protein; macrophage receptor with collagenous structure; MARCO recombinant protein
Host
HEK293 Cells
Purity/Purification
>92% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Sequence
Gln70-Ser518
Species
Mouse
Endotoxin
<1.0EU per ug of the protein as determined by the LAL method
Predicted N Terminal
His
Tag
N-His
Protein Construction
A DNA sequence encoding the extracellular domain of mouse MARCO (NP_034896.1)(Gln 70-Ser 518) was expressed, fused with a polyhistidine tag at the N-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.
SDS-Page
SDS-Page
Related Product Information for MARCO recombinant protein
Background: Macrophage receptor MARCO, also known as Macrophage receptor with collagenous structure and Marco, is a single-pass type II membrane protein. MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. It is expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes. Although it is expressed on subsets of macrophages, it can be upregulated on other macrophages after bacterial infection. The strategic position of MARCO-expressing cells in lymphoid organs suggests an important role for this bacteria-binding molecule in the removal of pathogens. MARCO has a short N-terminal cytoplasmic domain, a transmembrane domain, and a large extracellular part composed of a 75-residue long spacer domain, a 27-residue collagenous domain, and a 99-residue long scavenger receptor cysteine-rich (SRCR) domain. It is possible that cooperation between the SRCR domain and the collagenous domain is needed for high-affinity bacterial binding, or that the SRCR domain has to be in a trimeric form to effectively bind to bacteria
References
Kraal, G. et al., 2000, Microbes Infect. 2 (3): 313-6. Sankala, M., 2002, J Biol Chem. 277 (36): 33378-85. Arredouani, MS., 2004, Cell Mol Biol. 50 Online Pub : OL657-65. Thakur, SA., 2009, Toxicol Sci. 107 (1): 238-46.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
52,730 Da
NCBI Official Full Name
macrophage receptor MARCO
NCBI Official Synonym Full Names
macrophage receptor with collagenous structure
NCBI Official Symbol
Marco
NCBI Official Synonym Symbols
Ly112; Scara2; AI323439
NCBI Protein Information
macrophage receptor MARCO
UniProt Protein Name
Macrophage receptor MARCO
Protein Family
UniProt Gene Name
Marco
UniProt Entry Name
MARCO_MOUSE
Uniprot Description
MARCO: Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.
Protein type: Membrane protein, integral
Cellular Component: collagen; membrane; integral to membrane
Molecular Function: scavenger receptor activity
Biological Process: immune system process; innate immune response; endocytosis; apoptotic cell clearance
Research Articles on MARCO
1. MARCO-/- dendritic cells demonstrated enhanced migratory capacity in response to CCL-21 in vitro.
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Product Notes
The MARCO marco (Catalog #AAA8122662) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Gln70-Ser5 18. It is sometimes possible for the material contained within the vial of "MARCO, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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