Western Blot (WB)
(Western blot analysis of extracts of human brain tissue, using PACS2-Specific antibody.)
Rabbit PACS2 Polyclonal Antibody | anti-PACS2 antibody
PACS2-Specific Antibody
Gene Names
PACS2; EIEE66; PACS-2; PACS1L
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Synonyms
PACS2; Polyclonal Antibody; PACS2-Specific Antibody; 6720425G15Rik; AW208651; AW489976; E230011J22; FLJ25488; KIAA0602; mKIAA0602; PACS 2; PACS-2; PACS1 like protein; PACS1-like protein; PACS1L; PACS2_HUMAN; Phosphofurin acidic cluster sorting protein 1 like; Phosphofurin acidic cluster sorting protein 2; anti-PACS2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
PACS2-Specific antibody detects endogenous levels of PACS2-Specific.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
904
Applicable Applications for anti-PACS2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IHC: 1:50-1:200
Immunogen
A synthesized peptide derived from human PACS2-Specific.
Subcellular Location
Endoplasmic Reticulum Lumen. Mitochondrion.
Tissue Specificity
Broadly expressed, with greatest levels in skeletal muscle followed by heart, brain, pancreas and testis.
Predicted Cross Reactivity
Pig, Bovine, Horse, Rabbit, Dog
Similarity
Pig (100%), Bovine (100%), Horse (100%), Rabbit (100%), Dog (100%)
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of extracts of human brain tissue, using PACS2-Specific antibody.)
Western Blot (WB)
(Western blot analysis of extracts of human brain tissue, using PACS2-Specific antibody.)
Immunohistochemistry (IHC)
(MBS9603669 at 1/100 staining Human pancreas cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.)
Immunohistochemistry (IHC)
(MBS9603669 at 1/100 staining Human pancreas cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.)
Related Product Information for anti-PACS2 antibody
Function: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Subunit Structure: Interacts with BID and PKD2 (PubMed:15692567, PubMed:15692563). Interacts with HIV-1 Nef (PubMed:18296443).
Similarity: Belongs to the PACS family.
Subunit Structure: Interacts with BID and PKD2 (PubMed:15692567, PubMed:15692563). Interacts with HIV-1 Nef (PubMed:18296443).
Similarity: Belongs to the PACS family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 116 kDa
Predicted: 98 kDa
Predicted: 98 kDa
NCBI Official Full Name
phosphofurin acidic cluster sorting protein 2 isoform 1
NCBI Official Synonym Full Names
phosphofurin acidic cluster sorting protein 2
NCBI Official Symbol
PACS2
NCBI Official Synonym Symbols
EIEE66; PACS-2; PACS1L
NCBI Protein Information
phosphofurin acidic cluster sorting protein 2
UniProt Protein Name
Phosphofurin acidic cluster sorting protein 2
Protein Family
UniProt Gene Name
PACS2
UniProt Synonym Gene Names
KIAA0602; PACS1L; PACS-2
Uniprot Description
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Research Articles on PACS2
Similar Products
Product Notes
The PACS2 pacs2 (Catalog #AAA9603669) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PACS2-Specific Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PACS2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the PACS2 pacs2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PACS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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