CD204/MSR1 Recombinant Protein | MSR1 recombinant protein

CD204/MSR1 Protein, Rat, Recombinant (His Tag)

Cat. Num. AAA8123446

• Gene Names: Msr1; RGD1564316
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CD204/MSR1; CD204/MSR1 Protein; Rat; Recombinant (His Tag); Rat MSR1/SCARA1 Protein (His Tag); macrophage scavenger receptor 1; MSR1 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Trp79-Ser454

• Species: Rat
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: His
• Tag: N-His
• Protein Construction: A DNA sequence encoding the rat MSR1 (NP_001178868.1)(Trp79-Ser454) was expressed with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for MSR1 recombinant protein

Background: Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD24, MSR1, and SCARA1, is a single-pass type II membrane protein that contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1/SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low-density lipoproteins (LDL). MSR1/SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.

References

Wang L. et al., 2003, Nat Genet. 35 (2): 128-9. Chen Y.C. et al., 2008, Cancer Epidemiol Biomarkers Prev. 17 (4): 1001-3. Shirato K. et al., 2009, Pflugers Arch. 459 (1): 93-103. Sun J. et al., 2006, Prostate. 66 (7): 728-37.

NCBI and Uniprot Product Information

• NCBI GI #: 300794338
• NCBI GeneID: 498638
• NCBI Accession #: NP_001178868.1
• NCBI GenBank Nucleotide #: NM_001191939.1
• NCBI Official Full Name: macrophage scavenger receptor types I and II
• NCBI Official Synonym Full Names: macrophage scavenger receptor 1
• NCBI Official Symbol: Msr1
• NCBI Official Synonym Symbols: RGD1564316
• NCBI Protein Information: macrophage scavenger receptor types I and II
• Protein Family: Macrophage scavenger receptor