SDS-PAGE

LIFR recombinant protein

Recombinant Rat LIFR Protein (His tag)

Purity

> 95 % as determined by SDS-PAGE

Synonyms

LIFR; Recombinant Rat LIFR Protein (His tag); LIFR recombinant protein

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Cat. Num. AAA2547347 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Host

Human Cells

Purity/Purification

> 95 % as determined by SDS-PAGE

Form/Format

Lyophilized from sterile PBS, pH 7.4

Sequence Length

1093

Application Notes

The recombinant rat LIFR comprises 797 amino acids and predicts a molecular mass of 90 kDa. The apparent molecular mass of the recombinant protein is approximately 116 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Predicted N Terminal

Leu 44

Endotoxin

< 1.0 EU per mug of the protein as determined by the LAL method

Preparation and Storage

Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for LIFR recombinant protein

Background: LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (cardiotrophin like cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1 and cardiotrophin like cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.

Description: A DNA sequence encoding the rat LIFR (G3V7K2) (Met1-Ser829) was expressed with a polyhistidine tag at the C-terminus.

NCBI and Uniprot Product Information

NCBI GI #

564335498

NCBI GeneID

81680

NCBI Accession #

XP_006232089.1

NCBI GenBank Nucleotide #

XM_006232027.3

UniProt Accession #

G3V7K2; O70535

Molecular Weight

122,417 Da

NCBI Official Full Name

leukemia inhibitory factor receptor isoform X1

NCBI Official Synonym Full Names

leukemia inhibitory factor receptor alpha

NCBI Official Symbol

Lifr

NCBI Protein Information

leukemia inhibitory factor receptor

UniProt Protein Name

Leukemia inhibitory factor receptor

Protein Family

Leukemia inhibitory factor receptor

UniProt Gene Name

Lifr

NCBI Description

alpha chain of leukemia inhibitory factor glycoprotein and growth factor [RGD, Feb 2006]

Research Articles on LIFR

1. In the chronic kidney disease-cardiac hypertrophy model exercise rescues cardiac disease via cardiotrophin-1/LIFR/gp 130/JAK/STAT3 pathway.

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Product Notes

The LIFR lifr (Catalog #AAA2547347) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The recombinant rat LIFR comprises 797 amino acids and predicts a molecular mass of 90 kDa. The apparent molecular mass of the recombinant protein is approximately 116 kDa in SDS-PAGE under reducing conditions due to glycosylation. Researchers should empirically determine the suitability of the LIFR lifr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LIFR, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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LIFR recombinant protein

Recombinant Rat LIFR Protein (His tag)

SDS-PAGE

NCBI and Uniprot Product Information

NCBI Description

Research Articles on LIFR

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