SDS-Page
(Gel: 12%SDS-PAGE, Lysate: 40 ug, Lane 1-7: Human fetal liver tissue, RAW264.7, PC-3, 293T, LO2, Hela and Jurkat cell lysates, Primary antibody:EXOSC4 Antibody at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds)
Rabbit anti-Human, Mouse EXOSC4 Polyclonal Antibody | anti-EXOSC4 antibody
EXOSC4 Antibody
Gene Names
EXOSC4; SKI6; p12A; RRP41; Ski6p; RRP41A; Rrp41p; hRrp41p
Reactivity
Human, Mouse
Applications
Western Blot, Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
EXOSC4; Polyclonal Antibody; EXOSC4 Antibody; SKI6; p12A; RRP41; Ski6p; RRP41A; Rrp41p; hRrp41p; anti-EXOSC4 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Purity/Purification
Antigen affinity purification
Form/Format
pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration
0.8mg/mL (varies by lot)
Applicable Applications for anti-EXOSC4 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IHC: 1:50-1:200
Immunogen
Fusion protein of human EXOSC4
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C for 1 year.
SDS-Page
(Gel: 12%SDS-PAGE, Lysate: 40 ug, Lane 1-7: Human fetal liver tissue, RAW264.7, PC-3, 293T, LO2, Hela and Jurkat cell lysates, Primary antibody:EXOSC4 Antibody at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds)
SDS-Page
(Gel: 12%SDS-PAGE, Lysate: 40 ug, Lane 1-7: Human fetal liver tissue, RAW264.7, PC-3, 293T, LO2, Hela and Jurkat cell lysates, Primary antibody:EXOSC4 Antibody at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds)
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (EXOSC4 Antibody) at dilution 1/50.)
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (EXOSC4 Antibody) at dilution 1/50.)
Related Product Information for anti-EXOSC4 antibody
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs.
Product Categories/Family for anti-EXOSC4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
26,383 Da
NCBI Official Full Name
Homo sapiens exosome component 4, mRNA
NCBI Official Synonym Full Names
exosome component 4
NCBI Official Symbol
EXOSC4
NCBI Official Synonym Symbols
SKI6; p12A; RRP41; Ski6p; RRP41A; Rrp41p; hRrp41p
NCBI Protein Information
exosome complex component RRP41
UniProt Protein Name
SH3 domain-containing YSC84-like protein 1
UniProt Gene Name
SH3YL1
Research Articles on EXOSC4
Similar Products
Product Notes
The EXOSC4 sh3yl1 (Catalog #AAA9434822) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The EXOSC4 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's EXOSC4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the EXOSC4 sh3yl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "EXOSC4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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