Human Kruppel-like factor 1 (erythroid) ELISA Kit | KLF1 elisa kit

Human Krueppel-like factor 1, KLF1 ELISA Kit

Cat. Num. AAA9325953

• Gene Names: KLF1; EKLF; INLU; CDAN4; HBFQTL6
• Reactivity: Human
• Synonyms: Kruppel-like factor 1 (erythroid); Human Krueppel-like factor 1; KLF1 ELISA Kit; Human Krueppel-like factor 1 (KLF1) ELISA kit; EKLF; INLU; erythroid Kruppel-like factor; erythroid-specific transcription factor EKLF; monoclonal antibody A3D8; KLF1 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 10835246
• NCBI GeneID: 10661
• NCBI Accession #: NP_006554.1
• NCBI GenBank Nucleotide #: NM_006563.3
• UniProt Accession #: Q13351; Q6PIJ5; Q92899
• Molecular Weight: 38,221 Da
• NCBI Official Full Name: Krueppel-like factor 1
• NCBI Official Synonym Full Names: Kruppel-like factor 1 (erythroid)
• NCBI Official Symbol: KLF1
• NCBI Official Synonym Symbols: EKLF; INLU; CDAN4; HBFQTL6
• NCBI Protein Information: Krueppel-like factor 1; monoclonal antibody A3D8; erythroid Kruppel-like factor; erythroid krueppel-like transcription factor; erythroid-specific transcription factor EKLF
• UniProt Protein Name: Krueppel-like factor 1
• Protein Family: Krueppel-like factor
• UniProt Gene Name: KLF1
• UniProt Synonym Gene Names: EKLF; EKLF
• UniProt Entry Name: KLF1_HUMAN

NCBI Description

This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009]

Uniprot Description

KLF1: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation. Defects in KLF1 are the cause of congenital dyserythropoietic anemia type 4 (CDA4). It is a blood disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDA4 also have increased levels of fetal hemoglobin. Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein type: DNA-binding; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: nuclear chromatin; nucleus

Molecular Function: metal ion binding; transcription factor activity

Biological Process: chromatin remodeling; erythrocyte maturation; transcription, DNA-dependent; in utero embryonic development; embryonic hemopoiesis; positive regulation of transcription, DNA-dependent; erythrocyte differentiation; liver development

Disease: Fetal Hemoglobin Quantitative Trait Locus 6; Anemia, Congenital Dyserythropoietic, Type Iv; Blood Group--lutheran Inhibitor