JMJD2A Blocking Peptide | KDM4A blocking peptide

JMJD2A Peptide

Cat. Num. AAA151859

• Gene Names: KDM4A; JMJD2; JHDM3A; JMJD2A; TDRD14A
• Applications: Blocking (BL)
• Synonyms: JMJD2A; JMJD2A Peptide; JMJD2; JHDM3A; TDRD14A; KIAA0677; Lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; lysine (K)-specific demethylase 4A; KDM4A blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 481

• Applicable Applications for KDM4A blocking peptide: Blocking (BL)
• Application Notes: JMJD2A peptide is used for blocking the activity of JMJD2A antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 14 amino acids near the center of human JMJD2A.
• Preparation and Storage: Store JMJD2A peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 55665236
• NCBI GeneID: 9682
• UniProt Accession #: O75164; Q5VVB1
• Molecular Weight: 54,697 Da
• NCBI Official Synonym Full Names: lysine (K)-specific demethylase 4A
• NCBI Official Symbol: KDM4A
• NCBI Official Synonym Symbols: JMJD2; JHDM3A; JMJD2A; TDRD14A
• NCBI Protein Information: lysine-specific demethylase 4A
• UniProt Protein Name: Lysine-specific demethylase 4A
• Protein Family: Lysine-specific demethylase
• UniProt Gene Name: KDM4A
• UniProt Synonym Gene Names: JHDM3A; JMJD2; JMJD2A; KIAA0677
• UniProt Entry Name: KDM4A_HUMAN

NCBI Description

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]

Uniprot Description

JMJD2A: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family.

Protein type: Transcription, coactivator/corepressor; EC 1.14.11.-; Demethylase; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; histone demethylase activity (H3-K36 specific); methylated histone residue binding

Biological Process: cardiac muscle hypertrophy; histone demethylation; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; viral reproduction; negative regulation of transcription, DNA-dependent