Structure
XE 991 dihydrochloride, Inhibitor
XE 991 dihydrochloride
Purity
>98% (HPLC)
Synonyms
XE 991 dihydrochloride; XE-991; XE991; inhibitor
Purity/Purification
>98% (HPLC)
Target
Potassium Channel
Receptor
Potassium Channel
Chemical Name
10, 10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
SMILES
O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15
Molecular Formula
C26H20N2O.2HCl
CAS Number
122955-13-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for XE 991 dihydrochloride, inhibitor
A potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6uM, respectively; displays 14-fold less potency for KCNQ1+minK current with Kd of 11uM, enhances hippocampal ACh release from rat brain slices (EC50=490nM) and is a cognitive enhancer in vivo. Alzheimer Disease Discontinued
Product Categories/Family for XE 991 dihydrochloride, inhibitor
References
1. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May; 285 (2):724-30.
2. Wang HS, et al. Mol Pharmacol. 2000 Jun; 57 (6):1218-23.
3. MacVinish LJ, et al. Mol Pharmacol. 2001 Oct; 60 (4):753-60.
4. Yeung SY, et al. Br J Pharmacol. 2005 Oct; 146 (4):585-95.
2. Wang HS, et al. Mol Pharmacol. 2000 Jun; 57 (6):1218-23.
3. MacVinish LJ, et al. Mol Pharmacol. 2001 Oct; 60 (4):753-60.
4. Yeung SY, et al. Br J Pharmacol. 2005 Oct; 146 (4):585-95.
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Product Notes
The XE 991 dihydrochloride (Catalog #AAA3600900) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "XE 991 dihydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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