Structure
DMP 543 Biochemical
DMP 543
Purity
>98% (HPLC)
Synonyms
DMP 543; XR-543; XR 543; DMP-543; DMP 543 biochemical
Purity/Purification
>98% (HPLC)
Target
Potassium Channel
Receptor
Potassium Channel
Chemical Name
10, 10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
SMILES
O=C1C2=C(C=CC=C2)C(CC3=CC(F)=NC=C3)(CC4=CC(F)=NC=C4)C5=CC=CC=C15
Molecular Formula
C26H18F2N2O
CAS Number
160588-45-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for DMP 543 biochemical
A potent blocker of voltage-gated potassium channels Kv7 (KCNQ) that enhances ACh release from rat hippocampal slices in vitro with EC50 of 0.7uM; maintains the 5- to 10-fold potency differential over linopirdine in increasing extracellular hippocampal ACh levels in the rat with a minimum effective dose of 1mg/kg. Alzheimer Disease Phase 2 Discontinued
Product Categories/Family for DMP 543 biochemical
References
1. Earl RA, et al. J Med Chem. 1998 Nov 5; 41 (23):4615-22.
2. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May; 285 (2):724-30.
3. Pesti JA, et al. J Org Chem. 2000 Nov 17; 65 (23):7718-22.
4. Ipavec V, et al. Pharmacol Res. 2011 Oct; 64 (4):397-409.
2. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May; 285 (2):724-30.
3. Pesti JA, et al. J Org Chem. 2000 Nov 17; 65 (23):7718-22.
4. Ipavec V, et al. Pharmacol Res. 2011 Oct; 64 (4):397-409.
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Product Notes
The DMP 543 (Catalog #AAA3602308) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "DMP 543, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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