Structure
Senicapoc, Inhibitor
Senicapoc
Purity
>98% (HPLC)
Synonyms
Senicapoc; ICA-17043; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Potassium Channel
Receptor
Gardoschannel
Chemical Name
Benzeneacetamide, 4-fluoro-.alpha.-(4-fluorophenyl)-.alpha.-phenyl
SMILES
C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
Molecular Formula
C20H15F2NO
CAS Number
289656-45-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Senicapoc, inhibitor
A potent, selective Gardos channel blocker that blocks Ca (2+)-induced rubidium flux from human RBCs (IC50=11nM) and inhibits RBC dehydration (IC50=10-50nM); shows greater potency and selectivity than Clotrimazole; increases RBC K (+) content and hematocrit (Hct), decreases corpuscular hemoglobin concentration (MCHC) in a transgenic mouse model of sickle cell disease (SAD); orally active. Other Indication Phase 3 Discontinued
Product Categories/Family for Senicapoc, inhibitor
References
1. Stocker JW, et al. Blood. 2003 Mar 15; 101 (6):2412-8.
2. Ataga KI, et al. Blood. 2008 Apr 15; 111 (8):3991-7.
3. Minniti CP, et al. Br J Haematol. 2011 Dec; 155 (5):634-6.
2. Ataga KI, et al. Blood. 2008 Apr 15; 111 (8):3991-7.
3. Minniti CP, et al. Br J Haematol. 2011 Dec; 155 (5):634-6.
Similar Products
Product Notes
The Senicapoc (Catalog #AAA3603888) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Senicapoc, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
