Structure
MK-0448, Inhibitor
MK-0448
Purity
>98% (HPLC)
Synonyms
MK-0448; MK0448; inhibitor
Purity/Purification
>98% (HPLC)
Target
Potassium Channel
Receptor
Potassium Channel
Chemical Name
N-{6-[(1S)-1-(4-fluorophenyl)-2, 2-di(pyridin-3-yl)ethyl]pyridin-2-yl}methanesulfon- amide
SMILES
CS(=O)(NC1=NC([C@H](C2=CC=C(F)C=C2)C(C3=CC=CN=C3)C4=CC=CN=C4)=CC=C1)=O
Molecular Formula
C24H21FN4O2S
CAS Number
875562-81-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MK-0448, inhibitor
MK-0448 is a potent, specific I (Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8nM; also demonstrates a potent effect on currents associated with other Kv1.x and Kv2.x subunits, such as Kv1.7 and Kv2.1, with IC50 of 72 and 61nM, respectively; displays >70-fold concentration than inhibition of IKur; significantly causes prolongation of the atrial refractory period in normal anesthetized dogs. Heart Arrhythmia Phase 1 Clinical
Product Categories/Family for MK-0448, inhibitor
References
1. Pavri BB, et al. Circ Arrhythm Electrophysiol. 2012 Dec; 5 (6):1193-201.
2. Loose S, et al. Front Pharmacol. 2014 Mar 4; 5:26.
3. Wolkenberg SE, et al. Bioorg Med Chem Lett. 2017 Feb 15; 27 (4):1062-1069.
2. Loose S, et al. Front Pharmacol. 2014 Mar 4; 5:26.
3. Wolkenberg SE, et al. Bioorg Med Chem Lett. 2017 Feb 15; 27 (4):1062-1069.
Similar Products
Product Notes
The MK-0448 (Catalog #AAA3606358) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MK-0448, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
