Structure
KU-60019, Inhibitor
KU-60019
Purity
>98% (HPLC)
Synonyms
KU-60019; KU60019; KU 60019; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=30mg/mL
Target
ATM/ATR
Receptor
ATM/ATR
Chemical Name
4-Morpholineacetamide, 2, 6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R, 6S)-rel
SMILES
CC1CN(CC(O1)C)CC(=O)NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(=O)C=C(O5)N6CCOCC6
Molecular Formula
C30H33N3O5S
CAS Number
925701-46-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for KU-60019, inhibitor
KU-60019 is an improved analogue of KU-55933, and is a potent, specific inhibitor of ATM kinase with IC50 of 6.3nM, 270- and 1, 600-fold selectivity over DNA-PKcs and ATR; blocks radiation-induced phosphorylation of key ATM targets in human glioma cells, which is 10-fold more effective than KU-55933, reduces basal S473 AKT phosphorylation and inhibits glioma cell migration and invasion in vitro; preferentially sensitizes p53-mutant glioma to ionizing radiation in orthotopic xenograft models of GBM.
Product Categories/Family for KU-60019, inhibitor
References
1. Golding SE, et al. Mol Cancer Ther. 2009 Oct; 8 (10):2894-902.
2. Gamper AM, et al. J Biol Chem. 2012 Apr 6; 287 (15):12445-54.
3. Biddlestone-Thorpe L, et al. Clin Cancer Res. 2013 Jun 15; 19 (12):3189-200.
4. Golding SE, et al. Cell Cycle. 2012 Mar 15; 11 (6):1167-73.
2. Gamper AM, et al. J Biol Chem. 2012 Apr 6; 287 (15):12445-54.
3. Biddlestone-Thorpe L, et al. Clin Cancer Res. 2013 Jun 15; 19 (12):3189-200.
4. Golding SE, et al. Cell Cycle. 2012 Mar 15; 11 (6):1167-73.
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Product Notes
The KU-60019 (Catalog #AAA3606627) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "KU-60019, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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