Testing Data
EX-527, Inhibitor
EX-527
Purity
98% (TLC)
Synonyms
EX-527; 6-Chloro-2; 3; 4; 9-tetrahydro-1H-carbazole-1-carboxamide (racemic); inhibitor
Purity/Purification
98% (TLC)
Specific Activity
SIRT1 Inhibitor
CAS Registry Number
49843-98-3
Molecular Formula
C13H13ClN2O
Solubility
May be dissolved in DMSO (18mg/ml); or Ethanol (10mg/ml).
Preparation and Storage
Store desiccated as supplied at 4 degree C for up to 2 years. Store solutions at -20 degree C for up to 2 months.
Testing Data
Testing Data
Related Product Information for EX-527, inhibitor
Selective Sirt1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or Sirt family members. Increases p53 acetylation following DNA damage1. Causes cell cycle arrest at G12. Inhibits differentiation and facilitates expansion of hematopoietic progenitor cells3. An extremely useful tool for determining the involvement of Sirt1 in cellular physiology4. Cell permeable.
Product Categories/Family for EX-527, inhibitor
References
1. JM Solomon et al. Mol. Cell. Biol. 2006 26:28
2. B Peck et al. Mol. Cancer Ther. 2010 9:844
3. T Peled et al. Exp. Hematol. 2012 40:342
4. JL Andersen et al. Mol. Cell 2011 43:834
2. B Peck et al. Mol. Cancer Ther. 2010 9:844
3. T Peled et al. Exp. Hematol. 2012 40:342
4. JL Andersen et al. Mol. Cell 2011 43:834
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Product Notes
The EX-527 (Catalog #AAA516416) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "EX-527, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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