Structure
UK-396082, Inhibitor
UK-396082
Purity
>98% (HPLC)
Synonyms
UK-396082; UK 396; 082; UK396082; inhibitor
Purity/Purification
>98% (HPLC)
Target
Other Targets
Receptor
Other Targets
Chemical Name
(S)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl)pentanoic acid
SMILES
CCCN1C=C(N=C1)C[C@H](CCCN)C(=O)O
Molecular Formula
C12H21N3O2
CAS Number
400044-47-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for UK-396082, inhibitor
UK-396082 is a potent and selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (activated TAFI; TAFIa) with Ki of 10nM; displays excellent selectivity over plasma carboxypeptidase N (>1,000-fold); exhibits antithrombotic efficacy in a rabbit model of venous thrombosis, yet has no effect on surgical bleeding in the rabbit; possesses excellent preclinical and clinical pharmacokinetic profile, and shows potential for the treatment of thrombosis and other fibrin-dependent diseases in humans.Thrombosis Phase 1 Discontinued
Product Categories/Family for UK-396082, inhibitor
References
1. Bunnage ME, et al. J Med Chem. 2007 Nov 29; 50 (24):6095-103.
2. Atkinson JM, et al. Matrix Biol. 2013 Jun 24; 32 (5):277-87.
3. Bridge K, et al. PLoS One. 2017 May 4; 12 (5):e0177117.
2. Atkinson JM, et al. Matrix Biol. 2013 Jun 24; 32 (5):277-87.
3. Bridge K, et al. PLoS One. 2017 May 4; 12 (5):e0177117.
Similar Products
Product Notes
The UK-396082 (Catalog #AAA3604369) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "UK-396082, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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