Structure
Letaxaban, Inhibitor
Letaxaban
Purity
>98% (HPLC)
Synonyms
Letaxaban; TAK-442; TAK442; inhibitor
Purity/Purification
>98% (HPLC)
Target
Factor Xa
Receptor
Factor Xa
Chemical Name
(S)-1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one
SMILES
O=C1NCCCN1C2CCN(C([C@H](O)CS(=O)(C3=CC=C4C=C(Cl)C=CC4=C3)=O)=O)CC2
Molecular Formula
C22H26ClN3O5S
CAS Number
870262-90-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Letaxaban, inhibitor
Letaxaban (TAK-442, TAK442) is a potent, selective and direct factor Xa (FXa) inhibitor with Ki of 1.8nM for hFXa, >440-fold selectivity than thrombin and negligible effects on trypsin, plasmin, and tPA; In human plasma, TAK-442 doubles FXa-induced clotting time, prothrombin time (PT), and activated partial thromboplastin time at 0.19, 0.55, and 0.59uM, respectively; demonstrates antithrombotic effects in rabbit model of venous thrombosis.Thrombosis Phase 2 Discontinued
Product Categories/Family for Letaxaban, inhibitor
References
1. Kawamura M, et al. J Cardiovasc Pharmacol. 2010 Aug; 56 (2):156-61.
2. Konishi N, et al. Thromb Res. 2010 Aug; 126 (2):124-9.
3. Konishi N, et al. Thromb Haemost. 2010 Sep; 104 (3):504-13.
2. Konishi N, et al. Thromb Res. 2010 Aug; 126 (2):124-9.
3. Konishi N, et al. Thromb Haemost. 2010 Sep; 104 (3):504-13.
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Product Notes
The Letaxaban (Catalog #AAA3606316) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Letaxaban, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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