Structure
Idelalisib, Inhibitor
Idelalisib
Purity
>98% (HPLC)
Synonyms
Idelalisib; CAL-101; GS-1101; GS1101; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=59.7mg/mL
Target
PI3K
Receptor
hVps34; p110alpha; p110beta; p110gamma; p110delta
Chemical Name
4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]
SMILES
O=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)CC)=NC5=C1C(F)=CC=C5
Molecular Formula
C22H18FN7O
CAS Number
870281-82-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Idelalisib, inhibitor
Idelalisib (CAL-101, GS-1101) is a potent, selective inhibitor of PI3K p110delta with IC50 of 2.5nM, 40- to 300-fold selectivity over other class I PI3Ks (p110alpha/betagamma, IC50=820/565/89nM), and 400- to 4000-fold over C2beta, hVPS34, DNA-PK, and mTOR; blocks FcRI p110delta-mediated CD63 expression in basophils with an EC50 of 8nM; blocks constitutive PI3K signaling, resulting in decreased phosphorylation of Akt and other downstream effectors, an increase in PARP and caspase cleavage and an induction of apoptosis in multiple B-cell malignancies. Blood Cancer Approved
Product Categories/Family for Idelalisib, inhibitor
References
1. Hoellenriegel J, et al. Blood. 2011 Sep 29; 118 (13):3603-12.
2. Herman SE, et al. Blood. 2010 Sep 23; 116 (12):2078-88.
3. Lannutti BJ, et al. Blood. 2011 Jan 13; 117 (2):591-4.
4. Bodo J, et al. Br J Haematol. 2013 Oct; 163 (1):72-80.
2. Herman SE, et al. Blood. 2010 Sep 23; 116 (12):2078-88.
3. Lannutti BJ, et al. Blood. 2011 Jan 13; 117 (2):591-4.
4. Bodo J, et al. Br J Haematol. 2013 Oct; 163 (1):72-80.
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Product Notes
The Idelalisib (Catalog #AAA3606318) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Idelalisib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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