Structure
Takinib, Inhibitor
Takinib
Purity
>98% (HPLC)
Synonyms
Takinib; EDHS-206; EDHS 206; EDHS206; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 6.8mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
TAK1
Receptor
TAK1
Chemical Name
1, 3-Benzenedicarboxamide, N1-(1-propyl-1H-benzimidazol-2-yl)
SMILES
O=C(C1=CC=CC(C(NC2=NC3=CC=CC=C3N2CCC)=O)=C1)N
Molecular Formula
C18H18N4O2
CAS Number
1111556-37-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Takinib, inhibitor
Takinib is a potent, selective TAK1 inhibitor with IC50 of 9.5nM, selectively induces apoptosis following TNF-a stimulation; weakly inhibits IRAK4, IRAK1, GCK, CLK2, and MINK1 with IC50 of 120-430nM against the MRC Dundee kinase panel, does not inhibit any of the MAP2Ks or MAP3Ks family members; inhibits phosphorylation of IKK, MAPK 8/9, and c-Jun, induces apoptosis in RA fibroblast-like synoviocytes and reduces IL-6 secretion, induces TNF-alpha-dependent cell death in rheumatoid arthritis and breast cancer cells.
Product Categories/Family for Takinib, inhibitor
References
1. Totzke J, et al. Cell Chem Biol. 2017 Aug 17; 24 (8):1029-1039.e7.
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Product Notes
The Takinib (Catalog #AAA3600414) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Takinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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