Structure
SB-242235, Inhibitor
SB-242235
Purity
>98% (HPLC)
Synonyms
SB-242235; SB 242235; SB242235; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=48mg/mL
Target
p38 MAPK
Receptor
p38MAPK
Chemical Name
Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy
SMILES
O=C(C1=CC=CN=C1)NC2=NC3=C(C=CC(OC)=C3OC)C4=NCCN24
Molecular Formula
C19H20FN5O
CAS Number
193746-75-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SB-242235, inhibitor
A selective p38 MAPK inhibitor; inhibits IL-1 beta induction of p38 MAPK in primary human chondrocytes with IC50 of 1uM; inhibits LPS-stimulated serum levels of TNFalpha in normal rats with mean ED50 of 3.99mg/kg. Rheumatoid Arthritis Discontinued
Product Categories/Family for SB-242235, inhibitor
References
1. Badger AM, et al. Osteoarthritis Cartilage. 2000 Nov; 8 (6):434-43.
2. Badger AM, et al. Arthritis Rheum. 2000 Jan; 43 (1):175-83.
3. Ward KW, et al. Xenobiotica. 2002 Mar; 32 (3):221-33.
2. Badger AM, et al. Arthritis Rheum. 2000 Jan; 43 (1):175-83.
3. Ward KW, et al. Xenobiotica. 2002 Mar; 32 (3):221-33.
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Product Notes
The SB-242235 (Catalog #AAA3603040) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SB-242235, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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