Structure
SJB3-019A, Inhibitor
SJB3-019A
Purity
>98% (HPLC)
Synonyms
SJB3-019A; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
DUB
Receptor
DUB
Chemical Name
2-(pyridin-3-yl)naphtho[2, 3-d]oxazole-4, 9-dione
Molecular Formula
C16H8N2O3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SJB3-019A, inhibitor
A novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1nM, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells; also increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity; triggers apoptosis in multiple myeloma cells via activation of caspase-3/8/9, degrades USP1 and downstream inhibitor of DNA-binding proteins as well as inhibits DNA repair via blockade of Fanconi anemia pathway and homologous recombination; downregulates multiple myeloma stem cell Notch-1, Notch-2, SOX-4, and SOX-2, and induces generation of more mature and differentiated plasma cells.
Product Categories/Family for SJB3-019A, inhibitor
References
1. Mistry H, et al. Mol Cancer Ther. 2013 Dec; 12 (12):2651-62.
2. Das DS, et al. Clin Cancer Res. 2017 Mar 7. doi: 10.1158/1078-0432.CCR-16-2692.
2. Das DS, et al. Clin Cancer Res. 2017 Mar 7. doi: 10.1158/1078-0432.CCR-16-2692.
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Product Notes
The SJB3-019A (Catalog #AAA3606996) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SJB3-019A, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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