Western Blot (WB)
(FIGLA Antibody (Center) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the FIGLA antibody detected the FIGLA protein (arrow).)
Rabbit anti-Human FIGLA Polyclonal Antibody | anti-FIGLA antibody
FIGLA Antibody (Center)
Western Blot (WB)
(FIGLA Antibody (Center) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the FIGLA antibody detected the FIGLA protein (arrow).)
Western Blot (WB)
(FIGLA Antibody (Center) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the FIGLA antibody detected the FIGLA protein (arrow).)
oocyte-specific gene expression. The protein is a basic
helix-loop-helix transcription factor that regulates multiple
oocyte-specific genes, including genes involved in folliculogenesis
and those that encode the zona pellucida. Mutations in this gene
cause premature ovarian failure type 6.
Fowler, P.A., et al. J. Clin. Endocrinol. Metab. 94(4):1427-1435(2009)
Tormala, R.M., et al. Mol. Cell. Endocrinol. 289 (1-2), 10-15 (2008) :
Zhao, H., et al. Am. J. Hum. Genet. 82(6):1342-1348(2008)
Suzumori, N., et al. Curr. Med. Chem. 14(3):353-357(2007)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]
Uniprot Description
FIGLA: Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. Defects in FIGLA are the cause of premature ovarian failure type 6 (POF6). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: transcription factor complex; nucleus
Molecular Function: protein dimerization activity; sequence-specific DNA binding; transcription factor binding
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; oocyte development
Disease: Premature Ovarian Failure 6
Research Articles on FIGLA
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Product Notes
The FIGLA figla (Catalog #AAA9212631) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 108-137. The FIGLA Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FIGLA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the FIGLA figla for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FIGLA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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