Structure
IU1-47, Inhibitor
IU1-47
Purity
>98% (HPLC)
Synonyms
IU1-47; IU1 47; IU147; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 16.67mg/mL (50.39mM)
Target
DUB
Receptor
DUB
Chemical Name
1-(1-(4-Chlorophenyl)-2, 5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1yl)ethanone
SMILES
CC1=CC(C(CN2CCCCC2)=O)=C(C)N1C3=CC=C(Cl)C=C3
Molecular Formula
C19H23ClN2O
CAS Number
670270-31-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for IU1-47, inhibitor
IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons.
Product Categories/Family for IU1-47, inhibitor
References
1. Boselli M, et al. J Biol Chem. 2017 Nov 24; 292 (47):19209-19225.
Similar Products
Product Notes
The IU1-47 (Catalog #AAA3605560) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "IU1-47, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
