Structure
Motesanib diphosphate, Inhibitor
Motesanib diphosphate
Purity
>98% (HPLC)
Synonyms
Motesanib diphosphate; AMG-706; Motesanib; AMG706; AMG 706; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
VEGFR
Receptor
Kit; VEGFR1; VEGFR2; VEGFR2/Flk1; VEGFR3
Chemical Name
3-Pyridinecarboxamide, N-(2, 3-dihydro-3, 3-dimethyl-1H-indol-6-yl)-2-[(4-pyridinylmethyl)amino]-, phosphate(1:2)
SMILES
OP(O)(O)=O.OP(O)(O)=O.CC1(C)CNC2=C1C=CC(NC(=O)C1=C(NCC3=CC=NC=C3)N=CC=C1)=C2
Molecular Formula
C22H29N5O9P2
CAS Number
857876-30-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Motesanib diphosphate, inhibitor
A potent, orally bioavailable, multikinase inhibitor inhibitor of VEGFR1/2/3, PDGFR and c-Kit with IC50 of 2-6nM, 84nM and 8nM, respectively; also displays activity against Ret (IC50=59nM), no activities against EGFR, Src, and p38; inhibits human endothelial cell proliferation induced by VEGF, but not by bFGF in vitro; potently inhibits VEGF-induced angiogenesis in the rat models. Lung Cancer Phase 3 Discontinued
Product Categories/Family for Motesanib diphosphate, inhibitor
References
1. Polverino A, et al. Cancer Res. 2006 Sep 1; 66 (17):8715-21.
2. Sherman SI, et al. N Engl J Med. 2008 Jul 3; 359 (1):31-42.
3. Coxon A, et al. lin Cancer Res. 2009 Jan 1; 15 (1):110-8.
4. Caenepeel S, et al. J Exp Clin Cancer Res. 2010 Jul 15; 29:96.
2. Sherman SI, et al. N Engl J Med. 2008 Jul 3; 359 (1):31-42.
3. Coxon A, et al. lin Cancer Res. 2009 Jan 1; 15 (1):110-8.
4. Caenepeel S, et al. J Exp Clin Cancer Res. 2010 Jul 15; 29:96.
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Product Notes
The Motesanib diphosphate (Catalog #AAA3606220) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Motesanib diphosphate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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