Testing Data
SB590885, inhibitor
SB590885
Purity
>99%
Synonyms
SB590885; inhibitor
Purity/Purification
>99%
Solubility
Unknown
Formula
C27H27N5O2
CAS Number
405554-55-4
Preparation and Storage
Store at -20 degree C for 2 years.
Testing Data
Testing Data
Related Product Information for SB590885, inhibitor
SB-590885 stabilizes the oncogenic B-Raf kinase domain in an active configuration, which is distinct from the previously reported mechanism of action of the multi-kinase inhibitor, BAY43-9006. Interestingly, selectivity towards B-Raf was shown as SB-590885 inhibited c-Raf with a Ki app of 1.72 +/-0.65 nM. These results showed that SB-590885 was a more potent inhibitor than the previously described Raf/VEGFR kinase inhibitor BAY 43-9006 (Ki app = 38 nM for mutant B-Raf, 6 nM for c-Raf) and exhibited more selectivity towards B-Raf inhibition. SB-590885 was further profiled against a panel of 48 other human kinases, comprising representatives from all of the main branches of the human kinome. Strikingly, SB-590885 displayed remarkable specificity for B-Raf inhibition, with significant activity measured only against c-Raf and minimal off-target activity.[1][2]
Product Categories/Family for SB590885, inhibitor
References
[1] http://aacrmeetingabstracts.org/cgi/content/abstract/2005/1/1250-a [2] King AJ et al. Cancer Res. 2006 Dec 1; 66(23):11100-5. The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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Product Notes
The SB590885 (Catalog #AAA8506522) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SB590885, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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