Chemical Structure
(Chemical structure of Epothilone B (SIH-238), a Microtubule stabilizing agent. CAS #: 152044-54-7. Molecular Formula: C27H41NO6S. Molecular Weight: 507.68 g/mol.)
Epothilone B Small Molecule
Epothilone B
Purity
>98%
Synonyms
Epothilone B; Microtubule stabilizer; (1S; 3S; 7S; 10R; 11S; 12S; 16R)-7; 11-Dihydroxy-8; 8; 10; 12; 16-pentamethyl-3-[(1E)-1-(2-methyl-1; 3-thiazol-4-yl)-1-propen-2-yl]-4; 17-dioxabicyclo[14.1.0]heptadecane-5; 9-dione; Patupilone; Epothilone B small molecule
Host
Synthetic
Purity/Purification
>98%
Form/Format
White solid
Solubility
Soluble to 10 mM in DMSO
CAS Number
152044-54-7
Molecular Formula
C27H41NO6S
SMILES
C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C
InChI
1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)
InChI Key
QXRSDHAAWVKZLJ-PVYNADRNSA-N
PubChem CID
448013
Preparation and Storage
Store at -20 degree C.
Chemical Structure
(Chemical structure of Epothilone B (SIH-238), a Microtubule stabilizing agent. CAS #: 152044-54-7. Molecular Formula: C27H41NO6S. Molecular Weight: 507.68 g/mol.)
Chemical Structure
(Chemical structure of Epothilone B (SIH-238), a Microtubule stabilizing agent. CAS #: 152044-54-7. Molecular Formula: C27H41NO6S. Molecular Weight: 507.68 g/mol.)
Related Product Information for Epothilone B small molecule
Epothilone are a new class of cancer drugs. They prevent cancer cells from dividing by interfering with tubulin (1). Epithilone B possess the same biological effects as paclitaxel in both invitro and cultured cells, because they share the same binding site (2). Epothilone has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. And it also causes cell cycle arrest at the G2-M transition phase, leading to eventual cell apoptosis (3).
Product Categories/Family for Epothilone B small molecule
References
1. Rosenberg S., Devita V.T., Hellman S. (2005) Cancer: Principles & Practice of Oncology: Lippincott Williams and Wilkins. 2. Julien B., Shah S. (2002) Antimicrob Agents Chemother. 46(9): 2772. 3. Balog D.M., et al. (1996) Angew Chem. 108: 2976.
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Product Notes
The Epothilone B (Catalog #AAA807976) is a Small Molecule produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Epothilone B, Small Molecule" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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