Testing Data
OSI-420, inhibitor
OSI-420 (Desmethyl Erlotinib, CP-473420)
Purity
>99%
Synonyms
OSI-420; OSI-420 (Desmethyl Erlotinib; CP-473420); inhibitor
Purity/Purification
>99%
Solubility
Unknown
Formula
C21H21N3O4.HCl
CAS Number
183320-51-6
Preparation and Storage
Store at -20 degree C for 2 years.
Testing Data
Testing Data
Related Product Information for OSI-420, inhibitor
OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells. Erlotinib disappearance from plasma after a short IV infusion was biexponential with a mean terminal half-life of 5.2 h and a mean clearance of 128 ml/min per m2. OSI-420 exposure (AUC) in plasma was 30% (range 12-59%) of erlotinib, and OSI-420 clearance was more than 5-fold higher than erlotinib. Erlotinib and OSI-420 were detectable in CSF. The CSF penetration (AUCCSF:AUCplasma) of erlotinib and OSI-420 was <5% relative to total plasma concentration, but CSF drug exposure was ?30% of plasma free drug exposure, which was calculated from published plasma protein binding values. The intravenous administration of erlotinib was well tolerated. [1][2][3]
Product Categories/Family for OSI-420, inhibitor
References
[1] Zhao M et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Aug 15; 793(2):413-20. [2] Ling J et al. Anticancer Drugs. 2008 Feb; 19(2):209-16. [3] Broniscer A et al. Clin Cancer Res. 2007 Mar 1; 13(5):1511-5. The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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Product Notes
The OSI-420 (Catalog #AAA8506326) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "OSI-420, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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