Testing Data
SGI-1776, inhibitor
SGI-1776
Purity
>99%
Synonyms
SGI-1776; inhibitor
Purity/Purification
>99%
Solubility
Unknown
Formula
C20H22F3N5O
CAS Number
1025065-69-3
Preparation and Storage
Store at -20 degree C for 2 years.
Testing Data
Testing Data
Related Product Information for SGI-1776, inhibitor
SGI-1776 free base is a selective Pim family kinase inhibitor with IC50 of 7 +/-1.8, 363 +/-27.6 and 69 +/-9.2 nM for Pim-1, Pim-2, and Pim-3, respectively. SGI-1776 is a member of the imidazo[1, 2-b]pyridazine chemical class, was selected for its ability to exploit an extended ATP-binding and solvent pocket, thereby making it a selective Pim family kinase inhibitor. Extensive biochemical characterization of SGI-1776 confirmed its specificity for the three isoforms of the Pim family. SGI-1776 is a fairly selective inhibitor of the Pim kinases and can cause a reduction in prostate cancer cell viability and alter overall cytotoxic responses to taxanes. SGI-1776 can disrupt cell cycle progression, induce apoptosis, promote taxane sensitivity, and overcome acquired chemoresistance by inhibiting MDR1 activity in specific prostate cancer models. SGI-1776 induces apoptosis in CLL and that the mechanism involves Mcl-1 reduction. SGI-1776 exhibited inhibitory activity against two other kinases: Flt-3 (IC50=44 nM) and Haspin (IC50= 34 nM). [1][2]
Product Categories/Family for SGI-1776, inhibitor
References
[1] Mumenthaler SM et al. Mol Cancer Ther. 2009 Oct; 8(10):2882-93. [2] Chen LS et al. Blood. 2009 Nov 5; 114(19):4150-7. The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
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Product Notes
The SGI-1776 (Catalog #AAA8506439) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SGI-1776, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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