Structure
RO4929097, Inhibitor
RO4929097
Purity
>98% (HPLC)
Synonyms
RO4929097; RG 4733; RO 4929097; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=49mg/mL
Target
gamma-secretase
Receptor
Abeta40; gammasecretase; gammasecretase (ICN); Notch
Chemical Name
Propanediamide, N1-[(7S)-6, 7-dihydro-6-oxo-5H-dibenz[b, d]azepin-7-yl]-2, 2-dimethyl-N3-(2, 2, 3, 3, 3-pentafluoropropyl)
SMILES
O=C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O)C(C)(C)C(NCC(F)(F)C(F)(F)F)=O
Molecular Formula
C22H20F5N3O3
CAS Number
847925-91-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for RO4929097, inhibitor
RO4929097 (RG 4733) is a potent, selective, orally active gamma-secretase inhibitor with IC50 of 4nM, inhibits Notch processing in the Notch cell-based reporter assay with IC50 of 5nM; displays >100-fold selectivity against a panel of 75 other proteins of various types including receptors, ion channels and enzymes; inhibits Notch processing in human tumor-derived cells, inhibits the production of ICN, reducing the expression of the downstream Notch target Hes1 in A549 cells; demonstrates in vivo efficacy in A549 xenograft model. Lung Cancer Phase 2 Discontinued
Product Categories/Family for RO4929097, inhibitor
References
1. Debeb BG, et al. Breast Cancer Res Treat. 2012 Jul; 134 (2):495-510.
2. Kaur G, et al. Cancer Lett. 2016 Feb 28; 371 (2):225-39.
3. He W, et al. Mol Oncol. 2011 Jun; 5 (3):292-301.
4. Luistro L, et al. Cancer Res. 2009 Oct 1; 69 (19):7672-80.
2. Kaur G, et al. Cancer Lett. 2016 Feb 28; 371 (2):225-39.
3. He W, et al. Mol Oncol. 2011 Jun; 5 (3):292-301.
4. Luistro L, et al. Cancer Res. 2009 Oct 1; 69 (19):7672-80.
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Product Notes
The RO4929097 (Catalog #AAA3606152) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RO4929097, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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