Structure
PAT-505, Inhibitor
PAT-505
Purity
>98% (HPLC)
Synonyms
PAT-505; PAT 505; PAT505; inhibitor
Purity/Purification
>98% (HPLC)
Target
Autotaxin
Receptor
Autotaxin
Chemical Name
3-((6-chloro-2-cyclopropyl-1-(1-ethyl-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl) thio)-2-fluorobenzoic acid sodium salt
SMILES
CCN1C=C(C=N1)N2C(=C(C3=C2C(=C(C=C3)Cl)F)SC4=CC=CC(=C4F)C(=O)[O-])C5CC5.[Na+]
Molecular Formula
C23H17ClF2N3NaO2S
CAS Number
1782070-85-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PAT-505, inhibitor
PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0nM against the lysoPLD activity of human ATX; displays high selectivity over other ENPP proteins and no significant agonist or antagonist activity at PPARalpha and PPARgamma; maintains good potency for inhibition of lysoPLD activity with IC50 of 9.7nM and 62nM in human blood and mouse plasma, respectively; robustly reduces liver fibrosis with no significant effect on steatosis, hepatocellular ballooning, or inflammation in high-fat diet model of NASH.
Product Categories/Family for PAT-505, inhibitor
References
1. Bain G, et al. J Pharmacol Exp Ther. 2017 Jan; 360 (1):1-13.
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Product Notes
The PAT-505 (Catalog #AAA3602680) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PAT-505, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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