Structure
BMS-906024, Inhibitor
BMS-906024
Purity
>98% (HPLC)
Synonyms
BMS-906024; BMS 906024; BMS906024; inhibitor
Purity/Purification
>98% (HPLC)
Target
Notch
Receptor
Notch
Chemical Name
(2R, 3S)-N1-[(3S)-2, 3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1, 4-benzodiazepin-3-yl]-2, 3-bis(3, 3, 3-trifluoropropyl)-butanediamide
SMILES
CN1C2=CC=CC=C2C(=NC(C1=O)NC(=O)C(CCC(F)(F)F)C(CCC(F)(F)F)C(=O)N)C3=CC=CC=C3
Molecular Formula
C26H26F6N4O3
CAS Number
1401066-79-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BMS-906024, inhibitor
BMS-906024 is a highly potent, selective inhibitor of gamma-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9nM, respectively; exhibits >200-fold selectivity against a panel of diverse protein targets; inhibits both leukemia (TALL-1) and triple-negative breast cancer (MDA-MB-468) cells with IC50 of 0.4nM, demonstrates broad-spectrum antineoplastic activity against a wide array of human cancer xenografts. Blood Cancer Phase 1 Clinical
Product Categories/Family for BMS-906024, inhibitor
References
1. Gavai AV, et al. ACS Med Chem Lett. 2015 Mar 11; 6 (5):523-7.
2. Knoechel B, Cold Spring Harb Mol Case Stud. 2015 Oct; 1 (1):a000539.et al.
3. Morgan KM, et al. Mol Cancer Ther. 2017 Dec; 16 (12):2759-2769.
2. Knoechel B, Cold Spring Harb Mol Case Stud. 2015 Oct; 1 (1):a000539.et al.
3. Morgan KM, et al. Mol Cancer Ther. 2017 Dec; 16 (12):2759-2769.
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Product Notes
The BMS-906024 (Catalog #AAA3601672) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BMS-906024, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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