Structure
R-59949, Inhibitor
R-59949
Purity
>98% (HPLC)
Synonyms
R-59949; R59949; R 59949; inhibitor
Purity/Purification
>98% (HPLC)
Target
DGK
Receptor
DGK
Chemical Name
3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one
SMILES
O=C1N(CCN2CC/C(CC2)=C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C(NC5=C1C=CC=C5)=S
Molecular Formula
C28H25F2N3OS
CAS Number
120166-69-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for R-59949, inhibitor
A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10uM in isolated platelet membranes and in intact platelets; markedly increases PKC activity in platelets stimulated with vasopressin, produces partial inhibition of formation of phosphatidic acid in human platelets challenged with thrombin, DC8 or OAG; also induces caspase-mediated apoptosis in glioblastoma cells and in other cancers, but lacks toxicity in noncancerous cells.
Product Categories/Family for R-59949, inhibitor
References
1. Dominguez CL, et al. Cancer Discov. 2013 Jul; 3 (7):782-97.
2. de Chaffoy de Courcelles D, et al. J Biol Chem. 1989 Feb 25; 264 (6):3274-85.
3. Rodriguez-Liares B, et al. Biochem Pharmacol. 1991 Mar 1; 41 (5):835-8.
4. Jiang Y, et al. Biochem Pharmacol. 2000 Apr 1; 59 (7):763-72.
2. de Chaffoy de Courcelles D, et al. J Biol Chem. 1989 Feb 25; 264 (6):3274-85.
3. Rodriguez-Liares B, et al. Biochem Pharmacol. 1991 Mar 1; 41 (5):835-8.
4. Jiang Y, et al. Biochem Pharmacol. 2000 Apr 1; 59 (7):763-72.
Similar Products
Product Notes
The R-59949 (Catalog #AAA3600724) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "R-59949, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
