Structure
MK-0591, Inhibitor
MK-0591
Purity
>98% (HPLC)
Synonyms
MK-0591; Quiflapon; MK-591; L-686708; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
FLAP
Receptor
FLAP
Chemical Name
1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1, 1-dimethylethyl)thio]-alpha, alpha-dimethyl-5-(2-quinolinylmethoxy)
SMILES
O=C(O)C(C)(C)CC(N1CC2=CC=C(Cl)C=C2)=C(SC(C)(C)C)C3=C1C=CC(OCC4=NC5=CC=CC=C5C=C4)=C3
Molecular Formula
C34H35ClN2O3S
CAS Number
136668-42-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MK-0591, inhibitor
A potent, specific and orally active 5-Lipoxygenase-activating protein (FLAP) inhibitor with IC50 of 1.6nM in FLAP binding assay; has no inhibitory effect on 15-lipoxygenase and platelet 12-lipoxygenase and cyclooxygenase in human PMNLs; potently inhibits leukotriene (LT) biosynthesis in intact human and elicited rat PMNLs with IC50 of 3.1 and 6.1nM, respectively; inhibits excretion of LTE4 in antigen-challenged allergic animal models. Asthma Discontinued
Product Categories/Family for MK-0591, inhibitor
References
1. Diamant Z, et al. J Allergy Clin Immunol. 1995 Jan; 95 (1 Pt 1):42-51.
2. Brideau C, et al. Can J Physiol Pharmacol. 1992 Jun; 70 (6):799-807.
3. Mienard L, et al. Can J Physiol Pharmacol. 1992 Jun; 70 (6):808-13.
2. Brideau C, et al. Can J Physiol Pharmacol. 1992 Jun; 70 (6):799-807.
3. Mienard L, et al. Can J Physiol Pharmacol. 1992 Jun; 70 (6):808-13.
Similar Products
Product Notes
The MK-0591 (Catalog #AAA3601514) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MK-0591, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
