Mouse anti-Human CYP1A1 Monoclonal Antibody | anti-CYP1A1 antibody

CYP1A1, CT (CYP1A1, Cytochrome P450 1A1, CYPIA1, Cytochrome P450 form 6, Cytochrome P450-C, Cytochrome P450-P1) (FITC)

Cat. Num. AAA6121337

• Gene Names: CYP1A1; AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein G Affinity Chromatography
• Synonyms: CYP1A1; Monoclonal Antibody; CT (CYP1A1; Cytochrome P450 1A1; CYPIA1; Cytochrome P450 form 6; Cytochrome P450-C; Cytochrome P450-P1) (FITC); Cytochrome P450-P1; anti-CYP1A1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 655CT6.1.2
• Purity/Purification: Purified by Protein G Affinity Chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).

• Applicable Applications for anti-CYP1A1 antibody: FLISA, Western Blot (WB)
• Application Notes: FLISA: 1:1,000; WB: 1:100-1000; Applications are based on unconjugated antibody.
• Immunogen: CYP1A1 Mab is generated from mice immunized with a KLH conjugated synthetic peptide selected from human CYP1A1.
• Conjugate: FITC
• Special Handling: Light sensitive
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(CYP1A1 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CYP1A1 antibody detected the CYP1A1 protein (arrow).)

Related Product Information for anti-CYP1A1 antibody

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.

Product Categories/Family for anti-CYP1A1 antibody

Antibodies; Enzymes; Cytochrome

References

Pande, M., et al. Mol. Carcinog. 49(11):974-980(2010) Sabitha, K., et al. Cancer Epidemiol 34(5):587-592(2010) Kumar, V., et al. Chemosphere 81(4):464-468(2010) Yamaguti, G.G., et al. Acta Haematol. 124(3):182-184(2010) Olsen, J.V., et al. Cell 127(3):635-648(2006)

NCBI and Uniprot Product Information

• NCBI GI #: 4503199
• NCBI GeneID: 1543
• NCBI Accession #: NP_000490
• NCBI GenBank Nucleotide #: NM_000499.3
• UniProt Accession #: P04798; Q53G18; A4F3V9; A4F3W0
• Molecular Weight: 18,441 Da
• NCBI Official Full Name: cytochrome P450 1A1
• NCBI Official Synonym Full Names: cytochrome P450, family 1, subfamily A, polypeptide 1
• NCBI Official Symbol: CYP1A1
• NCBI Official Synonym Symbols: AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
• NCBI Protein Information: cytochrome P450 1A1
• Protein Family: Cytochrome

NCBI Description

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]