Structure
NVP-BSK805 dihydrochloride, Inhibitor
NVP-BSK805 dihydrochloride
Purity
>98% (HPLC)
Synonyms
NVP-BSK805 dihydrochloride; BSK805 dihydrochloride; NVP-BSK 805 dihydrochloride; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
JAK
Receptor
JAK
Chemical Name
4-(2, 6-difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine dihydrochloride
Molecular Formula
C27H30Cl2F2N6O
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NVP-BSK805 dihydrochloride, inhibitor
A potent, selective and ATP-competitive inhibitor of JAK2 (V617F) and wt JAK2 (IC50=0.5nM); displays >20-fold selectivity towards JAK1, JAK3, TYK2 and excellent selectivity in broader kinase profiling; blunts constitutive STAT5 phosphorylation in JAK2 (V617F)-bearing cells; exhibits good oral bioavailability and a long half-life.
Product Categories/Family for NVP-BSK805 dihydrochloride, inhibitor
References
1. Baffert F, et al. Mol Cancer Ther. 2010 Jul; 9 (7):1945-55.
2. Pissot-Soldermann C, et al. Bioorg Med Chem Lett. 2010 Apr 15; 20 (8):2609-13.
2. Pissot-Soldermann C, et al. Bioorg Med Chem Lett. 2010 Apr 15; 20 (8):2609-13.
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Product Notes
The NVP-BSK805 dihydrochloride (Catalog #AAA3607026) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NVP-BSK805 dihydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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