Structure
Ruxolitinib phosphate, Inhibitor
Ruxolitinib phosphate
Purity
>98% (HPLC)
Synonyms
Ruxolitinib phosphate; INCB-018424 phosphate; Ruxolitinib; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=31mg/mL
H2O: 5.4mg/mL (Need ultrasonic or warming)
H2O: 5.4mg/mL (Need ultrasonic or warming)
Target
JAK
Receptor
JAK1; JAK2
Chemical Name
1H-Pyrazole-1-propanenitrile,.beta.-cyclopentyl-4-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)-, (.beta.R)-, phosphate(1:1)
SMILES
C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O
Molecular Formula
C17H21N6O4P
CAS Number
1092939-17-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Ruxolitinib phosphate, inhibitor
A potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8nM, respectively; displays modest selectivity against Tyk2 (6-fold) and marked selectivity (>130-fold) against JAK3; inhibits IL-6 signaling (IC50=281nM), and proliferation of JAK2V617F (+) Ba/F3 cells (IC50=127nM); suppresses erythroid progenitor colony formation from JAK2V617F (+) polycythemia vera patients (IC50=67nM) in primary cultures; markedly reduces level of inflammatory cytokines, and preferentially eliminates neoplastic cells in a mouse model of JAK2V617F (+) MPN. Bone Cancer Approved
Product Categories/Family for Ruxolitinib phosphate, inhibitor
References
1. Quintas-Cardama A, et al. Blood. 2010 Apr 15; 115 (15):3109-17.
2. Fridman JS, et al. J Immunol. 2010 May 1; 184 (9):5298-307.
3. Verstovsek S, et al. N Engl J Med. 2010 Sep 16; 363 (12):1117-27.
2. Fridman JS, et al. J Immunol. 2010 May 1; 184 (9):5298-307.
3. Verstovsek S, et al. N Engl J Med. 2010 Sep 16; 363 (12):1117-27.
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Product Notes
The Ruxolitinib phosphate (Catalog #AAA3600355) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ruxolitinib phosphate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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