Structure
PRN371, Inhibitor
PRN371
Purity
>98% (HPLC)
Synonyms
PRN371; PRN 371; inhibitor
Purity/Purification
>98% (HPLC)
Target
JAK
Receptor
JAK
Chemical Name
2-(3-acrylamidophenyl)-N-(tert-butyl)-5H-pyrrolo[2, 3-b]pyrazine-7-carboxamide
Molecular Formula
C20H21N5O2
CAS Number
1610974-55-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PRN371, inhibitor
PRN371 is a novel potent, selective JAK3 inhibitor with IC50 of 0.5nM, displays >250-fold selectivity over JAK1, JAK2, and TYK2; effectively inhibits IL-2 induces JAK1/3-STAT5 phosphorylation in PBMCs with IC50 of 99nM, effectively blocks JAK3-mediated signaling in JAK3-driven cancer cells; effectively inhibits the growth of NKTL cells via suppressing the JAK3-STAT pathway, and exhibits a more durable inhibition on JAK3 compared to tofacitinib in vitro; significantly inhibits tumor growth in NKTL xenograft model harboring JAK3 activating mutation.
Product Categories/Family for PRN371, inhibitor
References
1. Nairismgi M-, et al. Leukemia. 2018 Feb 2. doi: 10.1038/s41375-017-0004-x.
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Product Notes
The PRN371 (Catalog #AAA3602331) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PRN371, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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