Structure
Nucleozin, Inhibitor
Nucleozin
Purity
>98% (HPLC)
Synonyms
Nucleozin; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 28.66mg/mL (Need ultrasonic)
Target
Influenza Virus
Receptor
Influenza Virus
Chemical Name
Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)
SMILES
O=C(N1CCN(C2=CC=C([N+]([O-])=O)C=C2Cl)CC1)C3=C(C)ON=C3C4=CC=CC=C4
Molecular Formula
C21H19ClN4O4
CAS Number
341001-38-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Nucleozin, inhibitor
A small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation; inhibits infection of MDCK cells by viruses influenza A/WSN/33, H3N2 (clinical isolate) and Vietnam/1194/04 (H5N1) with EC50 of 0.069uM, 0.16uM and 0.33uM in PRA, respectively; protects mice challenged with lethal doses of avian influenza A H5N1; also targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection. Influenza Preclinical
Product Categories/Family for Nucleozin, inhibitor
References
1. Kao RY, et al. Nat Biotechnol. 2010 Jun; 28 (6):600-5.
2. Amorim MJ, et al. J Virol. 2013 Apr; 87 (8):4694-703.
3. Su CY, et al. Proc Natl Acad Sci U S A. 2010 Nov 9; 107 (45):19151-6.
2. Amorim MJ, et al. J Virol. 2013 Apr; 87 (8):4694-703.
3. Su CY, et al. Proc Natl Acad Sci U S A. 2010 Nov 9; 107 (45):19151-6.
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Product Notes
The Nucleozin (Catalog #AAA3604154) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Nucleozin, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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