Structure
GSK-2336805, Inhibitor
GSK-2336805
Purity
>98% (HPLC)
Synonyms
GSK-2336805; JNJ-56914845; GSK2336805; JNJ56914845; inhibitor
Purity/Purification
>98% (HPLC)
Target
HCV
Receptor
HCV
Chemical Name
methyl((S)-1-((S)-8-(4-(4'-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)-[1, 1'-biphenyl]-4-yl)-1H-imidazol-2-yl)-1, 4-dioxa-7-azaspiro[4.4]nonan-7-yl)-3-methyl-1-oxobutan-2-yl)carbamate
SMILES
O=C(OC)N[C@@H](C(C)C)C(N([C@H](C1=NC(C2=CC=C(C3=CC=C(C4=CNC([C@H]5N(C([C@H](C(C)C)NC(OC)=O)=O)CCC5)=N4)C=C3)C=C2)=CN1)C6)CC76OCCO7)=O
Molecular Formula
C42H52N8O8
CAS Number
1256390-53-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GSK-2336805, inhibitor
GSK-2336805 (JNJ-56914845) is a novel potent HCV NS5A inhibitor with multigenotype activity, has EC50s of 58.5, 7.4, and 53.8 pM on genotype 1a (H77), genotype 1b (Con-1 ET), and genotype 2a (JFH-1) replicon cells; shows an average EC50 of 63.7 pM on genotype 2a Jc1 virus, inhibits the HCV replication cycle and production of virus; retains activity on chimeric replicons containing NS5A patient sequences from genotype 1 and patient and consensus sequences for genotypes 4 and 5 and part of genotype 6. HCV Infection Phase 2 Clinical
Product Categories/Family for GSK-2336805, inhibitor
References
1. Walker J, et al. Antimicrob Agents Chemother. 2014; 58 (1):38-47.
2. Kazmierski WM, et al. J Med Chem. 2014 Mar 13; 57 (5):2058-73.
3. Bourgeois S, et al. BMC Gastroenterol. 2017 Feb 10; 17 (1):26.
4. Wilfret DA, et al. Antimicrob Agents Chemother. 2013 Oct; 57 (10):5037-44.
2. Kazmierski WM, et al. J Med Chem. 2014 Mar 13; 57 (5):2058-73.
3. Bourgeois S, et al. BMC Gastroenterol. 2017 Feb 10; 17 (1):26.
4. Wilfret DA, et al. Antimicrob Agents Chemother. 2013 Oct; 57 (10):5037-44.
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Product Notes
The GSK-2336805 (Catalog #AAA3601048) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GSK-2336805, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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