Structure
NQDI-1, Inhibitor
NQDI-1
Purity
>98% (HPLC)
Synonyms
NQDI-1; NQDI 1; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 10mg/mL
Target
MEK
Receptor
ASK1; MAP3K5
Chemical Name
3H-Naphtho[1, 2, 3-de]quinoline-1-carboxylic acid, 2, 7-dihydro-2, 7-dioxo-, ethyl ester
SMILES
O=C(C1=C2C3=C(NC1=O)C=CC=C3C(C4=C2C=CC=C4)=O)OCC
Molecular Formula
C19H13NO4
CAS Number
175026-96-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NQDI-1, inhibitor
NQDI-1 is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with Ki of 500nM; inhibits in vivo expression levels of ASK1, phosphorylated (p)JNK, pcJun, p53 and caspase 3 in Hypoxia-ischemia rat model; enhances endochondral bone formation by increasing chondrocyte survival in mice.
Product Categories/Family for NQDI-1, inhibitor
References
1. Volynets GP, et al. J Med Chem. 2011 Apr 28; 54 (8):2680-6.
2. Hao H, et al. Mol Med Rep. 2016 Jun; 13 (6):4585-92.
3. Eaton GJ, et al. Cell Death Dis. 2014 Nov 13; 5:e1522.
2. Hao H, et al. Mol Med Rep. 2016 Jun; 13 (6):4585-92.
3. Eaton GJ, et al. Cell Death Dis. 2014 Nov 13; 5:e1522.
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Product Notes
The NQDI-1 (Catalog #AAA3602650) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NQDI-1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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