Structure
BIX02188, Inhibitor
BIX02188
Purity
>98% (HPLC)
Synonyms
BIX02188; BIX 02188; BIX-02188; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=45mg/mL
Target
MEK
Receptor
MEK
Chemical Name
1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2, 3-dihydro-2-oxo-, (3Z)
SMILES
CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N)O
Molecular Formula
C25H24N4O2
CAS Number
334949-59-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BIX02188, inhibitor
BIX02188 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 4.3nM, wekaly inhibits ERK5 catalytic activity (IC50=810nM) and does not inhibits closely related kinases MEK1, MEK2, ERK2, and JNK2; blocks phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells, also inhibits transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system; induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.
Product Categories/Family for BIX02188, inhibitor
References
1. Li L, et al. Biochem Biophys Res Commun. 2008 May 23; 370 (1):159-63. 2. Tatake RJ, et al. Biochem Biophys Res Commun. 2008 Dec 5; 377 (1):120-5. 3. Obara Y, et al. J Biol Chem. 2009 Aug 28; 284 (35):23564-73. 4. Razumovskaya E, et al. Biochem Biophys Res Commun. 2011 Aug 26; 412 (2):307-12.
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Product Notes
The BIX02188 (Catalog #AAA3604135) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BIX02188, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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