Structure
AKS1-IN-19, Inhibitor
AKS1-IN-19
Purity
>98% (HPLC)
Synonyms
AKS1-IN-19; AKS1 inhibitor 19; inhibitor
Purity/Purification
>98% (HPLC)
Target
MEK
Receptor
MEK
Chemical Name
(R)-2-(6-(4-(1-hydroxypropan-2-yl)-4H-1, 2, 4-triazol-3-yl)pyridin-2-yl)-6-isopropoxyisoindolin-1-one
SMILES
CC(C)OC1=CC2=C(CN(C2=O)C3=CC=CC(=N3)C4=NN=CN4C(C)CO)C=C1
Molecular Formula
C21H23N5O3
CAS Number
2089638-10-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AKS1-IN-19, inhibitor
A novel potent, selective and orally active ASK1 (MAP3K5) inhibitor with pIC50 of 8.3; displays good kinase selectivity with only 32 kinases having less than 30 fold selectivity in a panel of 356 kinases; inhibits phospho-JNK with pEC50 of 8.2 in cellular assays; displayed robust MAP3K pathway inhibition and reduction of infarct size in an isolated perfused heart model of cardiac injury.
Product Categories/Family for AKS1-IN-19, inhibitor
References
1. Lanier M, et al. ACS Med Chem Lett. 2017 Feb 8; 8 (3):316-320.
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Product Notes
The AKS1-IN-19 (Catalog #AAA3603272) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AKS1-IN-19, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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