Rabbit anti-Human CTNNBL1 Polyclonal Antibody | anti-CTNNBL1 antibody

CTNNBL1, NT (CTNNBL1, C20orf33, Beta-catenin-like protein 1, Nuclear-associated protein, Testis development protein NYD-SP19) (Azide free) (HRP)

Cat. Num. AAA6289829

• Gene Names: CTNNBL1; NAP; P14L; PP8304; C20orf33; dJ633O20.1
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CTNNBL1; Polyclonal Antibody; NT (CTNNBL1; C20orf33; Beta-catenin-like protein 1; Nuclear-associated protein; Testis development protein NYD-SP19) (Azide free) (HRP); Testis development protein NYD-SP19; anti-CTNNBL1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-CTNNBL1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CTNNBL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-43 amino acids from the N-terminal region of human CTNNBL1.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(CTNNBL1 Antibody (N-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the CTNNBL1 antibody detected the CTNNBL1 protein (arrow).)

Related Product Information for anti-CTNNBL1 antibody

The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity. [provided by RefSeq].

Product Categories/Family for anti-CTNNBL1 antibody

Antibodies; KIAA; orf

References

Ichikawa, S., et al. J. Bone Miner. Res. 25(8):1821-1829(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Badiglian Filho, L., et al. Oncol. Rep. 21(2):313-320(2009). Andreasen, C.H., et al. BMC Med. Genet. 10, 17 (2009): Vogel, C.I., et al. BMC Med. Genet. 10, 14 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 527498274
• NCBI GeneID: 56259
• NCBI Accession #: NP_110517.2
• NCBI GenBank Nucleotide #: NM_030877
• UniProt Accession #: Q8WYA6; Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; B4DE16
• Molecular Weight: 61,971 Da
• NCBI Official Full Name: Homo sapiens catenin, beta like 1 (CTNNBL1), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: catenin, beta like 1
• NCBI Official Symbol: CTNNBL1
• NCBI Official Synonym Symbols: NAP; P14L; PP8304; C20orf33; dJ633O20.1
• NCBI Protein Information: beta-catenin-like protein 1; nuclear associated protein; testis development protein NYD-SP19
• UniProt Protein Name: Beta-catenin-like protein 1
• Protein Family: Beta-catenin-like protein
• UniProt Gene Name: CTNNBL1
• UniProt Synonym Gene Names: C20orf33; NAP
• UniProt Entry Name: CTBL1_HUMAN

NCBI Description

The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

Uniprot Description

CTNNBL1: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; Spliceosome

Chromosomal Location of Human Ortholog: 20q11.23-q12

Cellular Component: nucleoplasm; spliceosome; membrane; cytoplasm; nucleus

Molecular Function: protein binding; enzyme binding

Biological Process: nuclear mRNA splicing, via spliceosome; somatic diversification of immunoglobulins; positive regulation of apoptosis; apoptosis; RNA splicing; gene expression