Structure
KNK-437, Inhibitor
KNK-437
Purity
>98% (HPLC)
Synonyms
KNK-437; KNK437; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=34mg/mL
Target
HSP
Receptor
HSP105; HSP40; HSP72
Chemical Name
1-Pyrrolidinecarboxaldehyde, 3-(1, 3-benzodioxol-5-ylmethylene)-2-oxo
SMILES
O=CN1C(/C(CC1)=CC2=CC=C(OCO3)C3=C2)=O
Molecular Formula
C13H11NO4
CAS Number
218924-25-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for KNK-437, inhibitor
An inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells; inhibits the acquisition of thermotolerance as developed by sodium arsenite, also inhibited at mRNA levels; shows no antitumor effects and does not increase the thermosensitivity of nontolerant tumors in vivo (up to 200mg/kg). Colon Cancer Preclinical
Product Categories/Family for KNK-437, inhibitor
References
1. Yokota S, et al. Cancer Res. 2000 Jun 1; 60 (11):2942-8.
2. Koishi M, et al. Clin Cancer Res. 2001 Jan; 7 (1):215-9.
3. Guo F, et al. Cancer Res. 2005 Nov 15; 65 (22):10536-44.
2. Koishi M, et al. Clin Cancer Res. 2001 Jan; 7 (1):215-9.
3. Guo F, et al. Cancer Res. 2005 Nov 15; 65 (22):10536-44.
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Product Notes
The KNK-437 (Catalog #AAA3603492) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "KNK-437, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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