Structure
Alvespimycin hydrochloride, Inhibitor
Alvespimycin hydrochloride
Purity
>98% (HPLC)
Synonyms
Alvespimycin hydrochloride; 17-DMAG; KOS-1022; NSC 707545; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=50mg/mL
Target
HSP
Receptor
HSP
Chemical Name
Geldanamycin, 17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-, hydrochloride(1:1)
SMILES
NC(O[C@@H](/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC1=C2OCCN(C)C)[C@@H](OC)/C=CC=C(C)C(NC(C1=O)=CC2=O)=O)=O.[H]Cl
Molecular Formula
C32H49ClN4O8
CAS Number
467214-21-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Alvespimycin hydrochloride, inhibitor
A potent, orally bioavailable Hsp90 inhibitor with binding EC50 of 62nM; also show comparable binding affinity for Grp94 with EC50 of 65nM; inhibits the migration and the extracellular matrix-invasiveness of HUVEC in vitro, also inhibits FGF-2 and VEGF-induced HUVEC proliferation and induces apoptosis. Blood Cancer Phase 1 Discontinued
Product Categories/Family for Alvespimycin hydrochloride, inhibitor
References
1. Jez JM, et al. Jez JM, 2. Bull EE, et al. Clin Cancer Res. 2004 Dec 1; 10 (23):8077-84.
3. Kaur G, et al. Clin Cancer Res. 2004 Jul 15; 10 (14):4813-21.
4. Ge J, et al. J Med Chem. 2006 Jul 27; 49 (15):4606-15.
3. Kaur G, et al. Clin Cancer Res. 2004 Jul 15; 10 (14):4813-21.
4. Ge J, et al. J Med Chem. 2006 Jul 27; 49 (15):4606-15.
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Product Notes
The Alvespimycin hydrochloride (Catalog #AAA3604562) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Alvespimycin hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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