Structure
KDU731, Inhibitor
KDU731
Purity
>98% (HPLC)
Synonyms
KDU731; KDU 731; inhibitor
Purity/Purification
>98% (HPLC)
Target
PI4K
Receptor
PI4K
Chemical Name
3-(4-carbamoylphenyl)-N-(5-cyanopyridin-2-yl)-N-methylpyrazolo[1, 5-a]pyridine-5-carboxamide
SMILES
O=C(C1=CC2=C(C3=CC=C(C(N)=O)C=C3)C=NN2C=C1)N(C4=NC=C(C#N)C=C4)C
Molecular Formula
C22H16N6O2
CAS Number
1610610-48-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for KDU731, inhibitor
KDU731 is a potent, selective parasite Cryptosporidium lipid kinase PI4K (phosphatidylinositol-4-OH kinase) inhibitor with IC50 of 25nM, displays >50-fold selectivity window against the human PI4K IIIbeta homologue; shows HepG2 CC50 of 15.6uM and C. parvum CPE EC50 of 0.1uM; demonstrates a potent reduction in intestinal infection of immunocompromised mice after oral treatment, also leads to rapid resolution of diarrhoea and dehydration in neonatal calves, a clinical model of cryptosporidiosis that closely resembles human infection.
Product Categories/Family for KDU731, inhibitor
References
1. Manjunatha UH, et al. Nature. 2017 Jun 15; 546 (7658):376-380.
2. Ward HD. Trends Parasitol. 2017 Sep; 33 (9):662-664.
2. Ward HD. Trends Parasitol. 2017 Sep; 33 (9):662-664.
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Product Notes
The KDU731 (Catalog #AAA3602327) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "KDU731, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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