Structure
YM-201636, Inhibitor
YM-201636
Purity
>98% (HPLC)
Synonyms
YM-201636; YM 201636; YM201636; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=47mg/mL
Target
PIKfyve
Receptor
p110alpha; PIKfyve
Chemical Name
3-Pyridinecarboxamide, 6-amino-N-[3-[4-(4-morpholinyl)pyrido[3', 2':4, 5]furo[3, 2-d]pyrimidin-2-yl]phenyl]
SMILES
O=C(C1=CC=C(N)N=C1)NC2=CC=CC(C3=NC(N4CCOCC4)=C(OC5=NC=CC=C56)C6=N3)=C2
Molecular Formula
C25H21N7O3
CAS Number
371942-69-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for YM-201636, inhibitor
YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33nM, does not inhibits type Iigamma/Ialpha PtdInsP kinases even at 10uM (p110alpha IC50=3.3uM); shows insensitivity against yeast orthologue of PIKfyve, Fab1; significantly decreases the production of PtdIns (3, 5)P2 by 80% in serum-starved NIH3T3 cells with no effect on serum-stimulated PKB Ser 473 phosphorylation at 0.8uM; inhibits basal and insulin-activated 2-deoxyglucose uptake withIC50 of 54nM; significantly reduces retroviruses budding from cells; blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.
Product Categories/Family for YM-201636, inhibitor
References
1. Jefferies HB, et al. EMBO Rep. 2008 Feb; 9 (2):164-70.
2. Osborne SL, et al. J Biol Chem. 2008 Feb 1; 283 (5):2804-13.
3. Ikonomov OC, et al. Biochem Biophys Res Commun. 2009 May 8; 382 (3):566-70.
4. Kerr MC, et al. EMBO J. 2010 Apr 21; 29 (8):1331-47.
2. Osborne SL, et al. J Biol Chem. 2008 Feb 1; 283 (5):2804-13.
3. Ikonomov OC, et al. Biochem Biophys Res Commun. 2009 May 8; 382 (3):566-70.
4. Kerr MC, et al. EMBO J. 2010 Apr 21; 29 (8):1331-47.
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Product Notes
The YM-201636 (Catalog #AAA3604283) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "YM-201636, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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